Shrimaan Shrimati was built on the premise of "love the neighbor's wife." Keshav Kulkarni (Jatin Kanakia) is married to Kokila (Reema Lagoo). Their neighbours are a popular film actress Prema Shalini (Archana Puran Singh) and her effeminate husband Dilruba (Rakesh Bedi). Keshav is attracted to Prema's glamorous looks and lifestyle, while Dilruba is attracted to Kokila who is a smart elegant housewife. Both of them make use of every possible opportunity (and create many of their own) to flirt with each other's wives, but every time their efforts come to nought.